59313-92-7Relevant academic research and scientific papers
A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines
Hartung, Christian G.,Breindl, Claudia,Tillack, Annegret,Beller, Matthias
, p. 5157 - 5162 (2000)
An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization- hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd.
