59320-15-9

Basic information

• Product Name: 4-(2-hydroxyethylamino)-3-nitro-benzoic acid methyl ester
• Synonyms: 4-(2-hydroxyethylamino)-3-nitro-benzoic acid methyl ester
• CAS NO: 59320-15-9
• Molecular Weight: 240.216
• Mol File: 59320-15-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(2-hydroxyethylamino)-3-nitro-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxyethylamino)-3-nitro-benzoic acid methyl ester(59320-15-9)
• EPA Substance Registry System: 4-(2-hydroxyethylamino)-3-nitro-benzoic acid methyl ester(59320-15-9)

Safety Data

• Hazardous Substances Data: 59320-15-9(Hazardous Substances Data)

Upstream product

• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 
• 141-43-5 ethanolamine 

Downstream Products

• 936348-52-6 3-Amino-4-(2-hydroxy-ethylamino)-benzoic acid methyl ester 
• 100417-12-7 2-imino-3-(2'-amino-4'-methoxycarbonylphenyl)-thiazolidine dihydrochloride 
• 100418-45-9 methyl 3-nitro-4-N-(2-thiocyanatoethyl)-aminobenzoate 
• 100418-38-0 4-(2-Methanesulfonyloxy-ethylamino)-3-nitro-benzoic acid methyl ester 

Relevant articles and documents

Diversity-Oriented Synthesis of Coumarin-Linked Benzimidazoles via a One-Pot, Three-Step, Intramolecular Knoevenagel Cyclization

Diversity-oriented synthesis of coumarin-linked benzimidazoles from N-(2-aminophenyl)-2-cyanoacetamide was achieved via a one-pot, three-step sequential reaction in excellent yields. In situ intramolecular cyclization of the cyanoacetamide afforded benzimidazoles which subsequently underwent a Knoevenagel condensation of the 2-cyanomethylbenzimidazoles with salicylaldehydes promoted by triethylamine to reach the target compounds. An important intermediate, 2-(2-imino-2H-chromen-3-yl)-1H-benzimidazole was characterized by X-ray analysis and further hydrolyzed to 2-(coumarin-3-yl)benzimidazole in acidic condition. Among the synthesized compounds, some were found to be promising inhibitors of porcine kidney d-amino acid oxidase (pkDAO).

PHARMACEUTICAL USE OF SUBSTITUTED AMIDES

The use of substituted amides for modulating the activity of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.