593247-87-1Relevant academic research and scientific papers
A drug targeting motif for glycosidase inhibitors: An iminosugar-boronate shows unexpectedly selective β-galactosidase inhibition
Johnson Jr., Leland L.,Houston, Todd A.
, p. 8905 - 8908 (2007/10/03)
Boronic acids were tethered to iminosugars in compounds such as 8 and 13 in order to increase their affinity for cell surfaces where glycoprotein processing enzymes are operative. Surprisingly, this modification diminished α-mannosidase inhibition while increasing β-galactosidase inhibitory activity (8: Ki=2.0×10-4 M versus E. coli β-galactosidase). The presence of a boronate in 8 and 13 has a profound impact on the specificity of this inhibition.
