593270-55-4

Downstream Products

• 593270-65-6 propane-2-sulfonic acid {3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-amide 
• 593270-63-4 methanesulfonic acid {3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-amide 
• 593270-59-8 ethanesulfonic acid {3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-amide 
• 593270-58-7 4-methyl-N-{3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-benzenesulfonamide 
• 593270-56-5 N-{3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-N'-(1,1-dimethylethyl)-sulfamide 
• 593270-68-9 1,1-dimethylethyl {{3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propylamino}sulfonyl}-carbamate 
• 593270-61-2 2,2,2-trifluoro-ethanesulfonic acid {3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-amide 

Relevant academic research and scientific papers

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Sets of isomeric thiazole derivatives 1 and 2 have been synthesised in a parallel iterative solution-phase synthesis approach guided by the SAR analysis derived from biological results and computer-aided design and analysis. This synergistic and streamlined working procedure led to highly active isomeric NPY5 receptor ligands. However, a 10-fold difference at least in their respective binding affinities was consistently found for all isomeric pairs 1 and 2. The analysis of conformational differences due to heteroatom interactions in 1 and 2 revealed a favourable C=O...S interaction in 1, whereas thiazoles 2 showed a repulsive C=O...N interaction.