59339-36-5

Upstream product

• 20620-59-1 5-phenyl-n-valeric acid methyl ester 
• 74-88-4 methyl iodide 
• 109386-03-0 α-(trimethylsilyl)stylyl (trimethylsilyl)methyl sulfide 
• 886036-48-2 3-Acetoxy-2-methylene-5-phenyl-pentanoic acid methyl ester 
• 103-63-9 1-phenyl-2-bromoethane 
• 80-62-6 methacrylic acid methyl ester 
• 163589-71-7 ((E)-2-Trimethylsilanyl-2-trimethylsilanylmethanesulfinyl-vinyl)-benzene 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 143097-60-3 (±)-2-methyl-5-phenylpentanoic acid 
• 61713-68-6 3-methyl-6-phenyl-2-hexanone 

Relevant academic research and scientific papers

PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS

The present invention relates to compounds of formula (I) useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and the compounds for use in methods for the treatment of various disorders. Formula (I): or a salt thereof, wherein: A is selected from the group consisting of:

Sm/HOAc/EtOH system-mediated reduction of Baylis-Hillman acetates

Selective formation of (2E)-2-methylalk-2-enoates or 2-methyl alkanoates could be achieved in moderate to good yields under mild conditions via Sm/HOAc/EtOH system-mediated reduction of Baylis-Hillman acetates depending on the amount of samarium consumed in the reactions. Copyright Taylor & Francis Group, LLC.

Cobalt-catalyzed reductive coupling of saturated alkyl halides with activated alkenes

An efficient cobalt-catalyzed reductive coupling reaction of alkyl halides with electron-withdrawing alkenes (CH2=CR1EWG, EWG = electron-withdrawing group) in the presence of water and zinc powder in acetonitrile to give the corresponding Michael-type addition product (RCH 2CR1EWG) was described. The methodology is versatile such that unactivated primary, secondary, and tertiary alkyl bromides and iodides and various conjugated alkenes including acrylates, acrylonitrile, methyl vinyl ketone, and vinyl sulfone all successfully participate in this coupling reaction. For the alkyl halides used in the reaction, the iodides generally gave heller yields compared to those of the corresponding bromides. It is a unique method employing CoI2dppe, zinc, and alkyl halides, affording conjugate addition products in high yields. Mechanistically, the reaction appears to follow an oxidative addition driven route rather than the previously reported radical route.

NEW METHOD FOR GENERATION OF THIOCARBONYL YLIDES FROM BIS(TRIMETHYLSILYLMETHYL)SULFOXIDES AND THEIR APPLICATION TO CYCLOADDITIONS

Thiocarbonyl ylides were generated by heating of bis(trimethylsilylmethyl)sulfoxides.Cycloadditions of the ylides in the presence of dipolarophiles proceeded smoothly to give di- or tetrahydrothiophenes.