59340-27-1

Basic information

• Product Name: 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE
• Synonyms: BUTTPARK 77\50-05;ART-CHEM-BB B022869;CHEMBRDG-BB 4900313;1,3,5-TRIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE;1,3,5-TRIMETHYLPYRAZOLE-4-SULPHONYL CHLORIDE;AKOS B022869;1H-Pyrazole-4-sulfonylchloride,1,3,5-trimethyl-(9CI);1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride(SALTDATA: FREE)
• CAS NO: 59340-27-1
• Molecular Formula: C₆H₉ClN₂O₂S
• Molecular Weight: 208.67
• Product Categories: SULFONYLHALIDE
• Mol File: 59340-27-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 39 °C
• Boiling Point: 312.4°C at 760 mmHg
• Flash Point: 142.7°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 0.000974mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.29±0.10(Predicted)
• CAS DataBase Reference: 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE(59340-27-1)
• EPA Substance Registry System: 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-SULFONYL CHLORIDE(59340-27-1)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: IRRITANT
• Hazardous Substances Data: 59340-27-1(Hazardous Substances Data)

Usage

General Description

1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride, also known as Tazobactam, is a chemical compound with potential antibacterial properties. It is a sulfonamide-based beta-lactamase inhibitor that is commonly used in combination with the antibiotic piperacillin to treat a variety of bacterial infections. Tazobactam works by inhibiting the activity of beta-lactamase enzymes, which are produced by some bacteria to inactivate beta-lactam antibiotics. This allows the piperacillin to effectively kill the bacteria and treat the infection. Tazobactam is an important tool in the fight against antibiotic resistance and plays a critical role in improving the effectiveness of beta-lactam antibiotics in the treatment of bacterial infections.

InChI:InChI=1/C6H9ClN2O2S/c1-4-6(12(7,10)11)5(2)9(3)8-4/h1-3H3

Downstream Products

• 1230558-95-8 C₃₉H₅₄F₂N₆O₇S 
• 89532-07-0 1,3,5-Trimethylpyrazol-4-sulfonamid 
• 1279889-90-5 1,3,5-trimethyl-1H-pyrazole-4-sulfonic acid [2-(2-phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-amide 
• 958563-25-2 N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide 
• 1276673-45-0 N-((1S,4S)-4-fluoro-4-(3-(trifluoromethyl)phenylsulfonyl)cyclohexyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide 
• 1255713-81-5 2-(4-trifluoromethoxy-phenyl)-8-(1,3,5-trimethyl-1H-pyrazole-4-sulfonyl)-2,8-diaza-spiro[4.5]decan-1-one 

Relevant articles and documents

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Arylsulfonamides of 4-heteroaryl-piperidines, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatric disorders such as substa