59352-87-3

Upstream product

• 38870-31-4 7-bromo-2,3-diphenyl-5-azaquinoxaline 
• 98-80-6 phenylboronic acid 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 134-81-6 benzil 

Relevant academic research and scientific papers

Synthesis of quinoxalines and pyrido[2,3-b]pyrazines by SuzukiMiyaura cross-coupling reaction

Abstract: Bromo-substituted quinoxalines and pyrido[2,3-b]pyrazines were synthesized by condensation reactions of aromatic 1,2-diamino and 1,2-diketone compounds. These compounds were used as common intermediates for postcondensation modification by SuzukiMiyaura coupling reaction to form aryl-substituted quinoxalines and pyrido[2,3-b]pyrazines. High-efficiency with improved product yield of aryl-substituted quinoxalines and pyrido[2,3-b]pyrazine derivatives was achieved by conducting a coupling reaction in presence of Pd(dppf)Cl2·CH2Cl2 in tetrahydrofuran (THF) using K2CO3 as base at reflux temperature. Graphical abstract: [Figure not available: see fulltext.].

Silica tethered Pd-DABCO complex: An efficient and reusable catalyst for suzuki-miyaura reaction

A palladium-based catalyst supported on DABCO-functionalized silica was successfully prepared by a facile procedure. The prepared heterogeneous catalyst showed a high activity for the Suzuki-Miyaura reaction of aryl bromides, affording excellent yield in all the cases investigated. Interestingly, the catalyst could be quantitatively recovered from the reaction mixture and recycled for five times without any significant loss in activity. Furthermore, this protocol could be extended to the palladium catalyzed synthesis of annulated pyrazines. Springer Science+Business Media, LLC 2012.

Palladium-catalyzed cross-coupling reactions of 7-bromo-2,3-diphenyl- pyrido[2,3-b]pyrazine

First examples of palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, Heck and Buchwald-Hartwig reactions, are reported in the pyrido[2,3-b]pyrazine series. This methodology circumvents problems found in uncatalyzed nucleophilic sub