59359-46-5Relevant academic research and scientific papers
New alkylene diamine derivatives
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, (2008/06/13)
The invention is directed to 1-(2,6-Dimethyl-Phenyl-amino)-2-Dimethyl-amino-Propane and the pharmaceutical composition thereof useful for the treatment of cardiac rhythm disorders.
Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs
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, (2008/06/13)
Primary amino acylanilides of the formula, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R3 is selected from the group consisting of hydrogen and methyl, R4 is selected from the group consisting of hydrogen, methyl, and a C1 -C4 alkoxy group, R6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R7 is hydrogen, methyl or ethyl, R8 is hydrogen, R9 is hydrogen, methyl or ethyl, R10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R8 can also be methyl; (b) when n is 1, and R7 is hydrogen, and R9 is hydrogen or methyl, then R10 can also be methyl; (c) when R1 is hydrogen, R2 is methyl, R3 is hydrogen, R6 is methyl, R7 is hydrogen, R8 is hydrogen, and n is 0, then R4 can be ethoxy or propoxy only; (d) when R1 is hydrogen, R2 is methyl, R3, R4, R7 and R8 are hydrogen, and n is 0, then R6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route
