59363-13-2

Basic information

• Product Name: 1-Chloro-4-(4-chlorophenyl)-2-butanol
• Synonyms: 1-Chloro-4-(4-chlorophenyl)-2-butanol;Benzenepropanol, 4-chloro-a-(chloroMethyl)- (Butoconazole interMediate);Benzenepropanol, 4-chloro-a-(chloromethyl)-
• CAS NO: 59363-13-2
• Molecular Formula: C₁₀H₁₂Cl₂O
• Molecular Weight: 219.10768
• Mol File: 59363-13-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-4-(4-chlorophenyl)-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-(4-chlorophenyl)-2-butanol(59363-13-2)
• EPA Substance Registry System: 1-Chloro-4-(4-chlorophenyl)-2-butanol(59363-13-2)

Safety Data

• Hazardous Substances Data: 59363-13-2(Hazardous Substances Data)

Usage

General Description

1-Chloro-4-(4-chlorophenyl)-2-butanol is a chemical compound with the molecular formula C10H12Cl2O. It is a chlorinated derivative of 2-butanol and contains two chlorine atoms and a phenyl group. 1-Chloro-4-(4-chlorophenyl)-2-butanol is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry for various reactions, including the preparation of esters and ethers. The presence of the chlorine atoms in the molecule gives it unique chemical properties that make it useful in a variety of applications. However, it is important to handle this compound with care, as it can be hazardous if not used properly.

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 106-89-8 epichlorohydrin 

Downstream Products

• 67085-11-4 1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole 
• 64872-76-0 butoconazole 
• 67085-12-5 1-[2-chloro-4-(4-chlorophenyl)-n-butyl]imidazole 

Relevant articles and documents

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A industrialized butoconazole nitrate intermediates (by machine translation)

The invention relates to a kind of industrial production butoconazole nitrate intermediate 1 - (2 - hydroxy - 4 - (4 - chlorophenyl) butyl) - 1 - imidazole method of hydrogen. The method comprises the following steps: (1) taking sodium hydride DMF solution, under the condition of the ice, slow instillment imidazole DMF solution, heating and stirring the reaction; after cooling, slowly adding 1 - chloro - 4 - (4 - chlorophenyl) - 2 - butanol, heating and stirring the reaction, after cooling, to the reaction solution; (2) taking the steps of (1) the resulting reaction solution, under the condition of stirring and mixing ice, to stop the precipitate is filtered, washing the filter cake, drying, recrystallization, to get the. The method of the invention the synthetic process conditions and parameters in the comprehensive preferably, and improves product purity and yield, more suitable for large-scale industrial production. (by machine translation)

A industrialized production butoconazole nitrate intermediates

The invention relates to a method for industrially producing a butoconazole nitrate intermediate 1-(2-chloro-4-(4-chlorphenyl)butyl)-1-hydro-imidazole. The method comprises the following steps: (1) taking 1-(2-hydroxy-4-(4-chlorphenyl)butyl)-1-hydro-imidazole and thionyl chloride as raw materials to undergo heating reflux in dichloromethane, and after full reaction, cooling the reactant, thus obtaining a reaction liquid; and (2) slowly adding cold water and anhydrous sodium carbonate to the reaction liquid obtained in the step (1) in sequence, carrying out suction filtration, discarding the solid, concentrating the liquid and drying the concentrate, thus obtaining the butoconazole nitrate intermediate. In the method provided by the invention, the conditions and parameters in the synthetic process are comprehensively and preferentially selected, thus increasing the purity and yield of the product. Therefore, the method is more suitable for large-scale industrial production.