5937-68-8

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 5953-05-9 2,4-dichloro-4'-methyl-benzophenone (Z)-oxime 
• 5953-05-9 2,4-dichloro-4'-methyl-benzophenone (Ξ)-oxime 

Downstream Products

• 69600-19-7 6-chloro-3-[4-(4-methoxy-trans-styryl)-phenyl]-benzo[d]isoxazole 
• 69600-17-5 6-chloro-3-(4-trans-styryl-phenyl)-benzo[d]isoxazole 
• 69600-51-7 6-chloro-3-{4-[trans-2-(2-phenyl-benzofuran-6-yl)-vinyl]-phenyl}-benzo[d]isoxazole 
• 69600-37-9 3-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-6-chloro-benzo[d]isoxazole 
• 69600-41-5 6-chloro-3-[4-(4-ξ-styryl-trans-styryl)-phenyl]-benzo[d]isoxazole 
• 69600-26-6 3-{4-[4-(4-tert-butyl-benzenesulfonyl)-trans-styryl]-phenyl}-6-chloro-benzo[d]isoxazole 
• 69617-59-0 3-(4-bromomethyl-phenyl)-6-chloro-benzo[d]isoxazole 
• 5953-10-6 4-(6-chloro-benzo[d]isoxazol-3-yl)-benzoic acid 
• 68700-24-3 2-chloro-N-[4-(6-chloro-benzo[d]isoxazol-3-yl)-benzylidene]-aniline 
• 69617-60-3 4-(6-chloro-benzo[d]isoxazol-3-yl)-benzaldehyde 
• 5953-17-3 4-(6-chloro-benzo[d]isoxazol-3-yl)-benzoyl chloride 

Relevant academic research and scientific papers

Palladium-catalyzed benzo[d]isoxazole synthesis by C-H activation/[4 + 1] annulation

We report a palladium-catalyzed intermolecular [4 + 1] annulation pathway for N-phenoxyacetamides with aldehydes to form 1,2-benzisoxazoles. By activating the C-H bonds ortho to phenol-derived O-N bonds, the method enables the simultaneous construction of C-C and CN bonds in 1,2-benzisoxazoles with the O-N bonds intact. The method has been successfully applied to the synthesis of active pharmaceutical intermediates, such as risperidone.