59381-97-4Relevant academic research and scientific papers
Synthesis of polysubstituted 1,4-dihydropyridines via three-component reaction
Balalaie, Saeed,Baoosi, Leila,Tahoori, Fatemeh,Rominger, Frank,Bijanzadeh, Hamid Reza
, p. 738 - 743 (2013/07/27)
An efficient one-pot synthesis of novel N-substituted 1,4-dihydropyridine derivatives via a threecomponent reaction of primary amines, dialkyl acetylenedicarboxylates, and methyl (arylmethylidene) pyruvates has been reported. The reaction is performed using ZnCl2 (40 mol %) in dichloroethane in good to high yields through a domino Michael/cyclization sequence. Notably, the ready availability of the starting materials, high bond-forming efficiency, good to high yields and the high level of practicability of the reaction and work up make this approach an attractive complementary method for access to Nsubstituted 1,4-dihydropyridines.
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
Ogawa, Anthony K.,Willoughby, Chris A.,Bergeron, Raynald,Ellsworth, Kenneth P.,Geissler, Wayne M.,Myers, Robert W.,Yao, Jun,Harris, Georgianna,Chapman, Kevin T.
, p. 3405 - 3408 (2007/10/03)
The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.
