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Usage

Uses

Used in Oncology:
Lomustine is employed as a chemotherapeutic agent for the treatment of brain tumors, Hodgkin's disease, and multiple myeloma. It is used as an alkylating agent for its ability to interfere with DNA synthesis in cancer cells, causing cell destruction and inhibiting tumor growth.
Used in Cancer Treatment Research:
Lomustine is also utilized in research aimed at understanding the mechanisms of cancer cell destruction and the development of novel treatment strategies. Its potent effects on cancer cells make it a valuable tool in the ongoing fight against cancer, despite the need for caution due to its toxicity.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, Lomustine is used as a reference compound for the development of new drugs with similar mechanisms of action but potentially lower toxicity. Its role in chemotherapy serves as a benchmark for the evaluation of new cancer treatments.

Relevant academic research and scientific papers

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.