59417-39-9Relevant academic research and scientific papers
SYNTHESIS OF 4,11-DIMETHYL-2,3,4,5-TETRAHYDRO-2,5-IMINOMETHANO-6H-benzoTHIADIAZOCINE-3,12-DECANE AND 7,9-DIMETHYL-8,10-DIOXO-2,5-DITHIA-7,9-DIAZOBICYCLODECANE
Ueda, Taisei,Sawaki, Noriyuki,Oda, Noriichi,Ito, Isoo
, p. 593 - 596 (2007/10/02)
Two novel heterocyclic ring systems involving the piperazine ring and the benzothiadiazocine or dithiadiazabicyclodecane skeleton were syntethized: The reaction of 3,6-dibromo-1,4-dimethyl-2,5-piperazinedione(I) with an equivalent mole of o-aminothiophenol in ethanol in the presence of sodium ethoxide or in pyridine gave 4,11-dimethyl-2,3,4,5-tetrahydro-2,5-iminomethano-6H-benzothiadiazocine-3,12-decane (IIa), while the reaction of I with two moles of o-aminothiophenol gave 3,6-bis(2-aminophenyl)-thio-1,4-dimethyl-2,5-piperazinedione (IIIa).The reaction of Iwith an equivalent mole of ethanedithiol in ethanol in the presence of sodium ethoxide gave 7,9-diazabicyclo(4.2.2)decane (IV), which was also synthesized from 3,6-dihydroxy-1,4-dimethyl-2,5-piperazinedione (V) and ethanedithiol in dioxane in the presence of zinc chloride.
