59417-51-5

Usage

Molecular structure

A complex structure consisting of a quinoxaline ring system attached to a 1,1-diphenylethanol moiety.

Quinoxaline ring

A heterocyclic aromatic ring system containing oxygen and nitrogen atoms.

Methyl group

A CH3 group attached to the quinoxaline ring at the 3-position.

1,1-Diphenylethanol moiety

A group consisting of two phenyl rings attached to a central carbon atom, which is also attached to a hydroxyl group.

Medicinal chemistry and drug development

The compound has potential biological activities that could be explored for therapeutic purposes.

Chiral auxiliary or building block

The presence of the 1,1-diphenylethanol moiety suggests potential use as a chiral auxiliary or building block for the synthesis of other complex molecules.

Further research

More investigation is needed to explore the potential applications and biological activities of the compound.

Upstream product

• 119-61-9 benzophenone 
• 18470-23-0 6-bromo-2,3-dimethylquinoxaline 
• 2379-55-7 2,3-dimethylquinoxaline 

Relevant academic research and scientific papers

6-Lithioquinoxalines and Their Transformations

6-Bromo-2,3-diphenylquinoxaline reacts with butyllithium to give the 6-lithio derivative in a yield of more than 80%, which reacts with electrophiles such as benzophenone, Michler ketone, methyl ethyl ketone, iodine, selenium, and dimethylformamide to give the corresponding quinoxaline derivatives. 6-Bromo-2,3-dimethylquinoxaline is metallated with butyl- and phenyllithium at the methyl groups and benzene ring. These organolithium compounds react with benzophenone to give the corresponding diphenyl- and triaryl-carbinols, whose yield and ratio were determined by HPLC. These results open prospects for preparing new quinoxaline derivatives substituted at the annelated benzene ring.

LATERAL METALLATION OF METHYLATED NITROGENOUS HETEROCYCLES

Me groups on nitrogenous heterocycles can be conveniently metallated by a variety of strongly basic reagents to afford synthetically useful carbanions.The negative charge of such anions resides predominantly on the ring N atoms.The site of lithiation on pyridines and quinolines bearing Me groups in both the 2- and 4-positions depends upon the ability of the ring N atom to complex with the metallating agents.Carbanions derived from methylated pyridines, quinolines, naphthyridines, isoquinolines, pyridocarbazoles, pteridines, pyridoindoles and quinoxalines are discussed.References are provided describing condensations of these reagents with a variety of both common and uncommon electrophiles.