59430-56-7

Basic information

• Product Name: 5,8-dihydroxy-3,4-dihydroquinolin-2(1H)-one
• Synonyms: 2(1H)-Quinolinone, 3,4-dihydro-5,8-dihydroxy-
• CAS NO: 59430-56-7
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.1727
• Mol File: 59430-56-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 452.1°C at 760 mmHg
• Flash Point: 227.2°C
• Density: 1.425g/cm³
• Vapor Pressure: 8.63E-09mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 5,8-dihydroxy-3,4-dihydroquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-dihydroxy-3,4-dihydroquinolin-2(1H)-one(59430-56-7)
• EPA Substance Registry System: 5,8-dihydroxy-3,4-dihydroquinolin-2(1H)-one(59430-56-7)

Safety Data

• Hazardous Substances Data: 59430-56-7(Hazardous Substances Data)

Upstream product

• 79784-28-4 5,8-dimethoxy-4-p-tosyloxycarbostyril 
• 79784-26-2 N-(2',5'-dimethoxyphenyl)-2-ethoxycarbonylacetamide 
• 79784-27-3 2-tert-butoxy-4-chloro-5,8-dimethoxyquinoline 
• 75945-51-6 2,5-dimethoxy-β,β-dimethoxypropioanilide 
• 79784-29-5 2,5-dimethoxy-β-ethoxyacryloanilide 
• 70049-47-7 4-chloro-5,8-dimethoxycarbostyril 
• 63070-58-6 2,5-dimethoxy-carboxyacetanilide 
• 63070-62-2 2,4-dichloro-5,8-dimethoxyquinoline 
• 79784-29-5 N-(2,5-dimethoxy-phenyl)-3-ethoxy-acrylamide 
• 102-56-7 2,5-dimethoxyaniline 
• 79784-30-8 5,8-dimethoxycarbostyril 
• 61306-74-9 5,8-dimethoxy-3,4-dihydrocarbostyril 

Downstream Products

• 65008-21-1 8-benzyloxy-5-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril 
• 65008-22-2 8-benzyloxy-1-methyl-5-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril 
• 80090-12-6 8-Allyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 65008-23-3 1-benzyl-8-benzyloxy-3,4-dihydrocarbostyril-5-ol-tetrahydropyranyl ether 
• 65008-89-1 5-{3-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-8-(2-methoxy-ethoxy)-3,4-dihydro-1H-quinolin-2-one 
• 65008-44-8 8-Benzyloxy-5-[3-(1,1-dimethyl-2-phenyl-ethylamino)-2-hydroxy-propoxy]-3,4-dihydro-1H-quinolin-2-one 
• 65008-91-5 8-carboxymethoxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril 
• 65034-74-4 8-Benzyloxy-5-{2-hydroxy-3-[2-(4-methoxy-phenoxy)-ethylamino]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 80090-11-5 8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 65008-24-4 8-benzyloxy-5-hydroxy-1-methyl-3,4-dihydrocarbostyril 
• 65008-25-5 8-benzyloxy-5-(2,3-epoxypropoxy)-1-methyl-3,4-dihydrocarbostyril 
• 59826-19-6 8-benzyloxy-5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinolin-2-one 
• 65008-26-6 8-benzyloxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril 
• 80090-23-9 1-Benzyl-8-benzyloxy-5-hydroxy-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: Aryloxypropanolaminomethylpiperidines

The synthesis and SAR of a series of human β3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vitro active in CHO cells expressing human β3-AR (EC50=49 nM, IA=1.1), and in vivo active in a transgenic mouse model.

4-Aminopiperidine ureas as potent selective agonists of the human β3-Adrenergic receptor

The preparation and structure-activity relationships (SARs) of potent agonists of the human β3-adrenergic receptor (AR) derived from a 4-aminopiperidine scaffold are described. Examples combine human β3-AR potency with selectivity over human β1-AR and/or human β2-AR agonism. Compound 29s was identified as a potent (EC50 = 1 nM) and selective (greater than 400-fold over β1- with no β2-AR agonism) full β3-AR agonist with in vivo activity in a transgenic mouse model of thermogenesis.