59439-57-5

Upstream product

• 622-52-6 p-methylphenylthiourea 
• 100-44-7 benzyl chloride 

Downstream Products

• 1039630-10-8 2-benzylmercapto-1-(4-methylphenyl)-4-(4-methoxyphenyl)-1,6-dihydro-1,3,5-triazine-6-thione 
• 59439-60-0 2-benzyl-1-(phenyl-thiocarbamoyl)-3-p-tolyl-isothiourea 
• 99906-06-6 1-p-Tolyl-5-butyl-2-S-benzyl-iso-4-thio-biuret 
• 79490-96-3 3-p-tolylimino-5-butylimino-1,2,4-dithiazolidine 
• 1370289-58-9 C₁₉H₂₃N₃OS 
• 1370289-29-4 C₂₁H₂₇N₃OS 
• 1334599-32-4 C₁₈H₂₂N₄O 
• 1334599-46-0 C₂₀H₂₆N₄O 
• 1472651-80-1 1-p-tolyl-5-tetra-O-acetyl-β-D-glucopyranosyl-2-S-benzyl-2-isothiobiuret 
• 1373868-21-3 C₄₂H₅₁N₃O₁₇S₂ 
• 879934-48-2 C₁₉H₂₃N₃O₂S₂ 
• 879933-68-3 C₂₆H₂₉N₃O₂S₂ 

Relevant academic research and scientific papers

Synthesis and characterization of isothiobiurets of N-glucosylated compounds and their antimicrobial activities

A series of several 1-aryl-5-tetra-O-acetyl-β-glucopyranosyl-2-S- benzyl-2-isothiobiurets have been prepared by the interaction of aryl S-benzylisothiocarbamides and tetra-O-acetyl-β-glucopyranosyl isocyanate. The required aryl S-benzylisothiocarbamides was prepared by S-benzylation of different thioureas and tetra-O-acetyl-β-D-glucopyranosyl isocyanate was prepared by interaction of tetra-O-acetyl-α-D-glucopyranosyl bromide and lead cyanate. The structures of the newly synthesized compounds have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. All the synthesized compounds have been evaluated for their in vitro antibacterial and antifungal activity against different bacteria and fungi by agar diffusion method.

Synthesis and antiinflammatory properties of N-substituted guanidines

Various N[(p-substituted/unsubstituted)phenyl), (substituted thiazol-2-yl/oxazol-2-yl/naphthothiazol-2-yl)],N'-[N''',N'''-dimethyl/ diethylaminoacetyl],N''-phenyl guanidines were prepared from corresponding N-substituted thiocarbamides and were evaluated for their antiinflammatory activity. All the substituted guanidines (100 mg/Kg) provided 1-79 % protection against carrageenin induced edema in rats. Phenyl butazone (100 mg/Kg) was used as a standard drug for comparative evaluation and showed greater antiinflammatory activity. The results suggest that the presence of methoxy group on phenyl nuclei at para position enhances antiinflammatory activity. The increase in chain length on alkyl group of N (R)2 skeleton also cause some enhancement in activity. Among heterocyclic molecules maximum level of antiinflammatory activity is shown by oxazol-2-yl substituted guanidines.

Synthesis of N-galactosylated isodithiobiurets

Several 1-aryl-5-tetra-O-acetyl-β-D-galactosyl-2-S-benzyl-2,4- isodithiobiurets have been prepared by the interaction of aryl-S-benzyl isothiocarbamides and tetra-O-acetyl-β-D-galactosyl isothiocyanate. The structures of the newly synthesized compounds have been established on the basis of usual chemical transformations and IR, NMR and Mass spectral studies.

Synthetic and spectroscopic studies of some new 2-[1-aryl-4{4- methoxyphenyl}-6-thioxo-1,6-dihydro-1,3,5-triazinyl]amino/hydrazonothiazolidin- 4-ones

(Chemical Equation Presented) A series of 4-thiazolidinones having triazinethione moieties have been synthesized by the systematic chemical modification of S-benzylmercapto-1-aryl-4-(4-methoxyphenyl)-1,6-dihydro-1,3,5- triazine-6-thione.