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Partial Syntheses of Cardenolides and Cardenolide-Analogues. XII. Synthesis of 21-Substituted Cardenolides by Oxidation of 17β-(3-Furyl)-Steroids and Nucleophilic Substitution
Lindig, Claus,Repke, Kurt R. H.
, p. 841 - 858 (2007/10/02)
Oxidation of 17β-(3-furyl)-5β,14β-androstane-3β,14β-diol 3-acetate (2b) with chromic acid yielded the 14,21-epoxy-cardenolide 4.After elimination of the 14β-hydroxy group of 2b the unsaturated furyl derivative 5, when treated with chromic acid, gave a mix
