59464-18-5

Usage

Uses

Used in Pharmaceutical Industry:
(1S)-1,4-anhydro-1-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol is used as a potential pharmaceutical agent due to its unique molecular structure and possible biological activity. It may contribute to drug discovery and development efforts, offering new avenues for the treatment of various diseases and conditions.
Used in Organic Synthesis:
In the field of organic chemistry, (1S)-1,4-anhydro-1-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol serves as a valuable intermediate or building block in the synthesis of more complex organic compounds. Its distinctive functional groups and heterocyclic ring make it a versatile component in creating novel molecules with specific properties.
Used as a Research Tool:
(1S)-1,4-anhydro-1-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol is also utilized as a research tool in organic and medicinal chemistry. It aids scientists in understanding the relationship between molecular structure and biological activity, facilitating the advancement of knowledge in these scientific disciplines.

Upstream product

• 59464-17-4 5-(O²,O³-isopropylidene-O⁵-trityl-β-D-ribofuranosyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 64272-68-0 1,3-dimethyl-ψ-uridine 
• 17356-08-0 thiourea 
• 1445-07-4 pseudouridine 
• 57100-24-0 (3Ξ)-O⁴,O⁵-isopropylidene-O⁷-trityl-D-ribo-3,6-anhydro-2-deoxy-heptonic acid ethyl ester 
• 66149-71-1 5-(2,3-O-isopropylidene-β-D-ribofuranosyl)-2-thiouracil 

Relevant academic research and scientific papers

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Alternative nucleic acid molecules and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

A stereocontrolled total synthesis of C-nucleosides

A stereocontrolled, general synthesis of chiral C-nucleosides has been achieved through a common lactonic C- beta -glycoside intermediate which is readily obtainable from non-carbohydrate materials. The optically pure lactone having the natural D configuration is obtained through optical resolution of the seco acid by the Pirkle's method followed by relactonization. alpha -Aminomethylenation of the lactone with t-C//4H//9OCH left bracket N(CH//3 )//2 right bracket //2 yields 2-(2,3-0-isopropylidene- beta -D-ribofuranosyl)-2-(dimethylaminomethylene)acetic acid lactone, which undergoes base-assisted condensation with urea followed by deprotection to furnish naturally occurring pseudouridine. Analogously, construction of heterocycles using thiourea and guanidine converts the aminomethylene lactone to unnatural pyrimidine C-nucelosides, 2-thiopseudouridine and pseudoisocytidine, respectively.