59468-87-0 Usage
Uses
Used in Pharmaceutical Industry:
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide is used as an intermediate in the synthesis of CYP3A4, a metabolite of midazolam. This application is crucial for the development of new drugs and the understanding of drug metabolism, as CYP3A4 is a major enzyme involved in the metabolism of various medications.
Used in Metabolite Research:
In the field of drug metabolism, 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide serves as a metabolite of midazolam (M343000). This role is essential for studying the metabolic pathways of midazolam and its potential effects on the body, as well as for the development of new drugs with improved pharmacokinetic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 59468-87-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,4,6 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59468-87:
(7*5)+(6*9)+(5*4)+(4*6)+(3*8)+(2*8)+(1*7)=180
180 % 10 = 0
So 59468-87-0 is a valid CAS Registry Number.
59468-87-0Relevant academic research and scientific papers
Imidazodiazepines and processes therefor
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, (2008/06/13)
Novel Imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of organic substituents. An especially preferred genus included within the purview of the invention encompasses a compound of the formula STR1 wherein R1 is hydrogen and lower alkyl preferably methyl; R3 and R5 are hydrogen; R4 is hydrogen, nitro and halogen, most preferably, chlorine, and in a most preferred embodiment when positioned on the fused benzo portion of the imidazobenzodiazepine is in the 8-position thereof, R6 is phenyl or halo, nitro, or lower alkyl-substituted phenyl, preferably, halo, with fluorine being the preferred halogen, the substituted fluoro being positioned in the 2-position of the phenyl moiety and R2 is hydrogen and lower alkyl.
