59474-01-0

Basic information

• Product Name: (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
• Synonyms: NSC 146109 HYDROCHLORIDE;(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE;(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride;(10-Methylanthracen-9-yl)methyl Carbamimidothiote Hydrochloride;(10-Methylanthracen-9-yl)methyl carbamimidothioate hydrochloride;NSC 146109
• CAS NO: 59474-01-0
• Molecular Formula: C17H17ClN2S
• Molecular Weight: 316.85
• Product Categories: Caspases/Apoptosis;Cell Cycle Regulation
• Mol File: 59474-01-0.mol

Chemical Properties

• Boiling Point: 493.6°C at 760 mmHg
• Flash Point: 252.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 6.93E-10mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: Desiccate at RT
• CAS DataBase Reference: (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE(59474-01-0)
• EPA Substance Registry System: (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE(59474-01-0)

Safety Data

• Hazardous Substances Data: 59474-01-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE is used as a pharmaceutical agent for its ability to inhibit MDMX expression in breast cancer cells. By activating the p53 protein, (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE promotes apoptosis, or programmed cell death, in cancer cells, making it a promising candidate for the development of anticancer drugs.
Used in Chemical Research:
In the field of chemical research, (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE can be utilized as a starting material or intermediate for the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable tool for exploring new chemical reactions and developing novel molecules with potential applications in various industries.
Used in Material Science:
(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE's structural properties may also make it suitable for use in material science, where it could be employed in the development of new materials with specific characteristics. For example, its anthracenyl moiety could potentially be used to create materials with unique optical, electronic, or mechanical properties.

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

InChI:InChI=1/C17H16N2S/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15/h2-9H,10H2,1H3,(H3,18,19)