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Z-DL-Gla(tBu)2-OBn, also known as Z-DL-glutamyl-gamma-benzyl ester, is a synthetic chemical compound that serves as a building block in the synthesis of peptide-based drugs and other bioactive molecules. It is a protected derivative of the naturally occurring amino acid glutamic acid, featuring a benzyl ester group (OBn) for solubility and a tert-butyl group (tBu) for protection of the gamma-carboxylic acid group. The Z group is a protecting group for the alpha-amino group, which is crucial for preventing unwanted side reactions during peptide synthesis. Z-DL-Gla(tBu)2-OBn is widely used in the pharmaceutical industry for the development of therapeutics targeting various diseases, including cancer and neurological disorders, due to its ability to mimic the structure and function of natural peptides.

59479-77-5

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59479-77-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 59479-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,4,7 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59479-77:
(7*5)+(6*9)+(5*4)+(4*7)+(3*9)+(2*7)+(1*7)=185
185 % 10 = 5
So 59479-77-5 is a valid CAS Registry Number.

59479-77-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Z-DL-Gla(tBu)2-OBn

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:59479-77-5 SDS

59479-77-5Relevant academic research and scientific papers

The synthesis and properties of Gla- and Phe-containing analogues of cyclic RGD pentapeptides

Davies, John S.,Enjalbal, Christine,Nguyen, Corrine,Al-Jamri, Loai,Naumer, Christian

, p. 2907 - 2915 (2007/10/03)

Cyclopentapeptides containing the Arg-Gly-Asp motif have been synthesised using solid-phase assembly of side-chain-protected linear precursors, followed by solution-phase cyclisation. The replacement of the Asp residue by γ-carboxyglutamic acid (Gla) is a novel feature which gives rise to an analogue which inhibits cell adhesion, yet its congeners do not show activity in binding assays with recombinant integrin receptors. NMR techniques support a β/γ-turn conformation in most of the analogues. The Royal Society of Chemistry 2000.

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