5948-74-3

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1254327-25-7 ethyl 1,3-bis(4-morpholinylmethyl)-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-20-2 ethyl 1,3-bis(1H-benzimidazol-1-ylmethyl)-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-21-3 ethyl 1,3-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-24-6 ethyl 1,3-bis[(2-methyl-1H-benzimidazol-1-yl)methyl]-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-22-4 ethyl 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-26-8 ethyl 1,3-bis(1,2,3,4-tetrahydro-9H-carbazol-9-ylmethyl)-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1254327-23-5 ethyl 1,3-bis[(2-benzyl-1H-benzimidazol-1-yl)methyl]-4-(2-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 1403575-38-1 ethyl 3-amino-2-cyano-5-(2-hydroxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1403575-54-1 ethyl 9-(2-hydroxyphenyl)-7-methyl-2,4-dithioxo-2,3,4,9-tetrahydro-1H-thiazolo[3,2-a:4,5-d']-dipyrimidine-8-carboxylate 
• 1425352-61-9 ethyl 5-(2-hydroxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate hydrochloride 

Relevant academic research and scientific papers

Silica polymer nanocomposites functionalized with polyphosphoric acid: A mild catalyst for efficient one-pot synthesis of dihydropyrimidinones under environmentally benign conditions

An efficient, mild catalyst was employed for the synthesis of dihydropyrimidinones via condensation of aldehyde, ethyl acetoacetate, and urea/thiourea in the presence of silica polymer nanocomposite functionalized with polyphosphoric acid. The present met

An efficient protocol for the synthesis, biological screening and molecular docking studies of 3,4-dihydropyrimidine-2-one/thione derivatives

Introduction: Heterocyclic compounds are vital to life, since they constitute the most interesting part of the pharmacologically active drugs. Dihydropyrimidine-2-one/thione (DHPM) as the heterocyclic nucleus is the basic part of the most natural as well

Antidiabetic activity of dihydropyrimidine scaffolds and structural insight by single crystal x-ray studies

Background: This research project is designed to identify the anti-diabetic effects of the newly synthesized compounds to conclude the perspective of consuming one or more of these new synthetic compounds for diabetes management. Introduction: A series of

Coumarin-chalcone hybrids targeting insulin receptor: Design, synthesis, anti-diabetic activity, and molecular docking

Four series of thirteen new coumarin-chalcone hybrids (DPCU 1–13, DPCT 1–13, DCCU 1–13 and DCCT 1–13) were designed and synthesized using Biginelli synthesis, Pechmann condensation, Acetylation, and Claisen-Schmidt reactions. Synthesized compounds were te

Tuning the Biginelli reaction mechanism by the ionic liquid effect: The combined role of supported heteropolyacid derivatives and acidic strength

Herein, a combination of heteropolyacids and ionic liquids as a catalytic system was studied for the Biginelli multicomponent reaction; the positive ionic liquid effect associated with the acidic strength of zeolite-supported heteropolyacids made this com

Eco-friendly synthesis of solid-support bis-dihydropyrimidines and their antimicrobial studies

This article is aimed at the synthesis of new bis-dihydropyrimidines using solid-support. The reactions were carried out using microwave energy. Presented protocol is associated with higher yields of desired products, easier work-up conditions, less react

Bis-dihydropyrimidines: Catalyst-free, Microwave-assisted Organic Synthesis, Characterization and In Vitro Biological Screenings

In present research, we aim to afford the catalyst-free, greener synthesis of diethyl 2,2′-(1,2-phenylenebis(methylene))bis(sulfanediyl)bis(6-methyl-4-substitutedphenyl-1,4-dihydropyrimidine-5-carboxylate)derivatives via microwave irradiations. The reacti

Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two novel nanostructured catalysts: applications in the synthesis of Biginelli-type, polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives

Abstract: Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two nanostructured novel, green and heterogeneous catalysts were designed, synthesized and fully characterized by FT-IR, energy-dispersive X-ray spectroscopy, X-ray diffraction patterns, scanning electron microscopy, transmission electron microscopy and thermal gravimetric analysis. Then their catalytic applications were studied in the Biginelli-type reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via one-pot three-component condensation reaction between several aldehydes, ethyl acetoacetate and urea or thiourea. To further study catalytic properties of NMSDSA and NMSMSA, they were used in the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives under same reaction conditions. NMSDSA and NMSMSA have advantages such as cost-effectiveness, cleaner reaction profile, benign and heterogeneous characters, reusability of the catalysts and being in agreement with the green chemistry protocols. The described nanostructured catalysts have natural-based acids and potential for industrial production. Graphical Abstract: Synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via Biginelli-type reaction, polyhydroquinolines and 2,3-dihydroquinazolin-4(1H)-ones using NMSDSA and NMSMSA as two novel nanostructured catalysts. [Figure not available: see fulltext.]

Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition

A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high

(C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction

A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to