594839-82-4Relevant academic research and scientific papers
Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action
Razavi, Hossein,Palaninathan, Satheesh K.,Powers, Evan T.,Wiseman, R. Luke,Purkey, Hans E.,Mohamedmohaideen, Nilofar N.,Deechongkit, Songpon,Chiang, Kyle P.,Dendle, Maria T. A.,Sacchettini, James C.,Kelly, Jeffery W.
, p. 2758 - 2761 (2007/10/03)
Benzoxazoles pevent misfolding: Benzoxazole-based inhibitors of transthyretin (TTR) amyloid fibril formation are among the most effective found to date. They stabilize TTR against both acid-mediated misfolding and urea denaturation by raising the activati
