594853-95-9Relevant academic research and scientific papers
Reaction of 2-substituted-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde oximes with electron-deficient olefins and acetylenes
Shirai, Masashi,Kuwabara, Hidekazu,Matsumoto, Satoshi,Yamamoto, Hidetoshi,Kakehi, Akikazu,Noguchi, Michihiko
, p. 4113 - 4121 (2003)
A facile oxime-nitrone isomerization through the 1,2-hydrogen shift in 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde oximes is discussed. The resultant NH-nitrones are trapped by maleimides to afford intermolecular cycloadducts. The reaction of the oximes with electron-deficient acetylenes undergoes via another path initiated by a nucleophilic attack of the oxime to acetylene moiety.
