594874-66-5Relevant academic research and scientific papers
Highly diastereoselective strecker reaction of enolizable aliphatic sulfinimines
Li, Bin-Feng,Yuan, Ke,Zhang, Ming-Jie,Wu, Hao,Dai, Li-Xin,Wang, Quan Rui,Hou, Xue-Long
, p. 6264 - 6267 (2007/10/03)
The reaction of chiral sulfinimines 1c-g derived from aliphatic aldehydes with TMSCN in the presence of CsF gave α-amino nitriles in high diastereoselectivity and yield. α,β-Diamino acid derivatives were also obtained in high diastereoselectivity from the reaction of 2-aziridinesulfinimines 1h and 1i followed by ring-opening of the products with thiophenol. The presence ofhydrogen of hydrogen at the α-position of the C=N double bond is crucial in this TMSCN addition reaction.
