59496-85-4Relevant academic research and scientific papers
Unusual transformation of substituted-3-formylchromones to pyrimidine analogues: Synthesis and antimicrobial activities of 5-(o-hydroxyaroyl) pyrimidines
Raj, Tilak,Singh, Narinder,Ishar
, p. 6093 - 6096 (2013)
Substituted-3-formylchromones (4a-e) on reaction with 1,3-bis- dimethylaminomethylene-thiourea (5) in refluxing toluene solution give novel substituted 5-(o-hydroxyaroyl)pyrimidines (6a-e) in high yields. A mechanistic rationalization of the formation of products (6a-e) is proffered. Antimicrobial activities of all the synthesized compounds (6a-e) were evaluated against various fungal and bacterial strains. Compound 6d display significant antifungal activity (MIC 15) against Geotrichum candidum in comparison fluconazole used as positive control. Some of the compounds also display good antibacterial activity. Cytotoxic profile of compound 6d against HeLa cells indicates that at concentration (20 μM) no significant cell death (～2%) was observed.
Preparation and use of ethylenediamine copper perchlorate complex
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Paragraph 0036-0038, (2022/01/08)
A kind of ethylenediamine copper perchlorate complex (I), the structural formula of which is as follows: Synthesis method of the ethylenediamine copper perchlorate complex (I), It is weighed 0.710g of ethylenediamine into a 100mL round bottom flask, added
Synthesis method and application of 2-hydroxyphenyl-5-pyrazinyl ketone
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Paragraph 0017, (2020/09/23)
A synthesis method of 2-hydroxyphenyl-5-pyrazinyl ketone as shown in the following chemical formula (I) comprises the following steps of: weighing 0.048 g of a palladium complex, 0.8413 g of chromane-3-formaldehyde and 2.5719 g of ammonium formate and put
