595-17-5Relevant academic research and scientific papers
Terpenoids in four Inula species from Bulgaria
Aneva, Ina,Ivanova, Victoria,Staleva, Plamena,Todorova, Milka,Trendafilova, Antoaneta
, p. 1229 - 1240 (2022/02/16)
Phytochemical study of the chloroform extract of the aerial parts of Inula germanica L., I. ensifolia L., I. conyza (Griess.) DC. and I. salicina L. led to the identification of 33 terpenoids. β- and α-amyrin, lupeol, taraxasterol, ψ-taraxasterol and their 3-O-acetates and 3-O-palmitates were identified by GC/MS. In addition, the structures of 3-O-palmitates of mainaladiol, arnidiol, faradiol and 16-hydroxylupeol were confirmed by NMR. ent-Kaur-16-en-19- -oic acid and its 15α-(3-methylpentanoyloxy) and 15α-(3-methylbutanoyloxy) derivatives were isolated from I. conyza. Ten closely related sesquiterpene lactones (germacranolides and melampolides) were found in I. germanica and their structural identification was performed by spectral analyses. I. ensifolia and I. salicina were free of sesquiterpene lactones and diterpenoids. All triterpenoids and diterpenoids, grazielia acid, desacetylovatifolin and 8-(2-methylbutanoyloxy)- 1(10),4,11(13)-germacrutrien-6,12-olide-14-oic acid are described for the first time in the studied species. The principal component analysis was used to find a relationship between the investigated up to now Inula species, growing in Bulgaria.
Saponins from the Bark of Nephelium maingayi
Ito, Aiko,Chai, Hee-Byung,Kardono, Leonardus B. S.,Setowati, Francisca M.,Afriastini, Johar J.,Riswan, Soedarsono,Farnsworth, Norman R.,Cordell, Geoffrey A.,Pezzuto, John M.,Swanson, Steven M.,Kinghorn, A. Douglas
, p. 201 - 205 (2007/10/03)
Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7α-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16β-hydroxyamyrin), respectively. The structures of 1-6 were determined on the basis of spectral data interpretation, and the absolute configurations of their component monosaccharides were determined as their thiazolidine derivatives after acid hydrolysis. Of the isolates, only compounds 1 and 5 showed very weak cytotoxic activity against a panel of human tumor cell lines.
