59529-62-3Relevant academic research and scientific papers
Tetrofuranose nucleoside phosphonic acids: Synthesis and properties
Polakova, Ivana,Budesinsky, Milos,Tocik, Zdenek,Rosenberg, Ivan
experimental part, p. 503 - 536 (2011/12/04)
New isoelectronic, non-isosteric phosphonate analogues of nucleoside 5'-phosphates featuring the phosphorus moiety directly attached on the sugar ring in the C4' position are described. The analogues were synthesised by a nucleosidation reaction from tetr
Alkylation, Acylation and Silylation of Azoles
Begtrup, Mikael,Larsen, Peter
, p. 1050 - 1057 (2007/10/02)
Performing alkylation, acylation and silylation reactions in separate deprotonation and nucleophilic displacement steps allows for better control of reaction conditions and facilitates problem handling in these processes.In the alkylation of azoles the alkylating agents and solvents possess individual reaction capabilities which seem to be approximately additive.Monoalkylation occurs if the sum of the normalized reaction potentials is equal or larger than the pKa value of the azole.Dialkylation is avoided by keeping the sum of the normalized reaction potentials below the pKa value of the alkylazole.The applicability of these principles is demonstrated by the development of effective procedures for the methylation, benzylation, acetylation, methoxycarbonylation and trimethylsilylation of azoles.
