5954-76-7Relevant academic research and scientific papers
Development of a Robust Protocol for the Determination of Weak Acids' p KaValues in DMSO
Jung, Sebastian T.,Podlech, Joachim
, p. 10951 - 10957 (2020/09/23)
Two methods for the determination of pKa values of weak acids are described, a direct titration with dimsyl potassium in the presence of an indicator and a back-titration in which an analyte/indicator mixture is deprotonated and then titrated with ammonium chloride. Both methods have been validated by measuring pKa values of compounds, for which values had been determined previously. The back-titration method was applied to measure pKa values of two 1,3-dithiane-derived bissulfoxides and a monosulfone.
Chiral oxazoline-1,3-dithianes: New effective nitrogen-sulfur donating ligands in asymmetric catalysis
Capito, Elena,Bernardi, Luca,Comes-Franchini, Mauro,Fini, Francesco,Fochi, Mariafrancesca,Pollicino, Salvatore,Ricci, Alfredo
, p. 3232 - 3240 (2007/10/03)
A series of new chiral oxazoline-1,3-dithianes has been easily synthesized and used as ligands for asymmetric catalysis. The conjugate addition of Et 2Zn to enones resulted in ees of up to 69%, whereas the Pd-catalyzed allylic alkylation led to
A CONFORMATIONAL ANALYSIS OF 2-(X),4-(Y)-SUBSTITUED PENTANES (X, Y = OH, SH), USING CHIROPTICAL PROPERTIES AND 1H NMR SPECTROSCOPY.
Tavernier, D.,Hosten, N.,Anteunis, M. J. O.,Spiessens, L. I.,Becu, C.,Ketelaere, Antenius-de
, p. 845 - 864 (2007/10/02)
Optically active threo-(2S,4S)-4-mercapto-2-pentanol, eryhtro-(2R,4S)-4-mercapto-2-pentanol and threo-(2S,4S)-pentanedithiol, were prepared from threo-(2R,4R)-pentanediol.The mechanism of thier formation discussed.The molecular optical rotation D of these compounds, of trans-(4S,6S)-, cis-(4S,6R)-dimethyl-1,3-oxathiane and of trans-(4S,6S)-dimethyl-1,3-dithiane, was determined and was related to the composition of the conformational mixture using Brewster's conformational rotatory power model.A complete conformational analysis of the six 2-(X)-4(Y)-substituted pentanes (X, Y = OH, SH) was obtained from their 1H NMR spectra in combination with their chiroptical properties.The threo compounds favour the aa conformation, whereas the ag-/g+a forms are preferred in the erythro isomers, expect for the 2,4-diols where the intramolecular hydrogen bonded form is predominant.
