595582-49-3

Basic information

• Product Name: (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide
• Synonyms: (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide
• CAS NO: 595582-49-3
• Molecular Weight: 394.448
• Mol File: 595582-49-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide(595582-49-3)
• EPA Substance Registry System: (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide(595582-49-3)

Safety Data

• Hazardous Substances Data: 595582-49-3(Hazardous Substances Data)

Usage

General Description

(E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide is a chemical compound that belongs to the class of sulfonamides. It is a white to off-white solid with various potential pharmaceutical applications. (E)-N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide contains a sulfonamide group, which is known for its antibacterial and diuretic properties. Additionally, the presence of phenyl and methoxy groups in the structure suggests potential bioactive properties. It may also have potential applications in the field of medicinal chemistry for the development of new drugs. The specific properties and applications of this compound could be explored further through research and experimentation.

Upstream product

• 1445726-97-5 ethyl 2-(N-(4-Methoxy-3-nitrophenyl)sulfamoyl)acetate 
• 595582-48-2 (E)-N-(4-methoxy-3-nitrophenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide 
• 595582-47-1 2-(N-(4-methoxy-3-nitrophenyl)sulfamoyl)acetic acid 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 577-72-0 4-methoxy-3-nitroaniline 
• 1445727-04-7 2-(N-(4-methoxy-3-nitrophenyl)sulfamoyl)acetyl chloride 
• 1445727-07-0 N-(4-methoxy-3-nitrophenyl)-2-oxo-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide 
• 1445727-10-5 2-hydroxy-N-(4-methoxy-3-nitrophenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide 
• 364-76-1 4-Fluoro-3-nitroaniline 

Downstream Products

• 595582-56-2 (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetate 
• 1445726-84-0 (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoate 
• 1445726-85-1 (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)-2-methylpropanoate 
• 1445726-86-2 (E)-methyl 2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)-2-phenylacetate 
• 1445726-87-3 (E)-methyl 2-(4-fluorophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetate 
• 1445726-88-4 (E)-methyl 2-(4-chlorophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetate 
• 1445726-89-5 (E)-methyl 2-(4-bromophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetate 
• 595582-55-1 (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetic acid 
• 1445726-90-8 (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)propanoic acid 
• 1445726-91-9 (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)-2-methylpropanoic acid 
• 1445726-92-0 (E)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)-2-phenylacetic acid 
• 1445726-93-1 (E)-2-(4-fluorophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetic acid 
• 1445726-94-2 (E)-2-(4-chlorophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetic acid 
• 1445726-95-3 (E)-2-(4-bromophenyl)-2-(2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenylamino)acetic acid 

Relevant articles and documents

Design, synthesis, and biological evaluation of (E)-N-Aryl-2- arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents

A series of novel (E)-N-aryl-2-arylethenesulfonamides (6) were synthesized and evaluated for their anticancer activity. Some of the compounds in this series showed potent cytotoxicity against a wide spectrum of cancer cell-lines (IC50 values ranging from 5 to 10 nM) including all drug resistant cell-lines. Nude mice xenograft assays with compound (E)-N-(3-amino-4- methoxyphenyl)-2-(2′,4′,6′-trimethoxyphenyl)ethenesulfonamide (6t) showed dramatic reduction in tumor size, indicating their in vivo potential as anticancer agents. A preliminary drug development study with compound 6t is predicted to have increased blood-brain barrier permeability relative to many clinically used antimitotic agents. Mechanistic studies indicate that 6t and some other analogues disrupted microtubule formation, formation of mitotic spindles, and arrest of cells in mitotic phase. Compound 6t inhibited purified tubulin polymerization in vitro and in vivo and circumvented drug resistance mediated by P-glycoprotein. Compound 6t specifically competed with colchicine binding to tubulin and with similar avidity as podophylltoxin, indicating its binding site on tubulin.