59562-64-0

Upstream product

• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 683-58-9 (Z)-N-hydroxyacetimidoyl chloride 
• 188118-38-9 4-Chloro-N,N-diethyl-N'-hydroxy-benzamidine 
• 3354-65-2 N-(1-nitroso-ethylidene)-hydroxylamine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 89804-65-9 3-methyl-5-(4-chlorophenyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Cycloadditions of nitrile oxides to amidoximes. A general synthesis of 3,5-disubstituted 1,2,4-oxadiazole-4-oxides

The cycloaddition of nitrile oxides to amidoximes is a general method for the synthesis of 3,5-disubstituted 1,2,4-oxadiazole-4-oxides with the same or different substituents. The yields are only moderate since an equivalent amount of the nitrile oxide is consumed by reaction with the amine released in the fragmentation of the primary cycloadducts and reforms the amidoxime. With excess nitrile oxides the 1,2,4-oxadiazole-4-oxides undergo a disproportionation reaction to yield nitroso carbonyl intermediates and 1,2,4-oxadiazoles.