59564-29-3Relevant academic research and scientific papers
ANTI-VIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
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Paragraph 0165, (2016/06/01)
Disclosed herein are compounds and pharmaceutical compositions, and uses thereof for the treatment of viral infections, including RNA viral infections. The compounds, pharmaceutical compositions, and methods disclosed herein can relate to chromenone drug candidate compounds that modulate innate immunity along the RLR-IRF3 axis. These compounds activate innate immune signaling downstream of numerous viral countermeasures and are a unique addition to conventional antiviral compounds in development or on the market. These compounds possess broad spectrum in vitro activity against diverse RNA viruses including the respiratory pathogens influenza, RSV, and hCoV, with EC50 values in the low nanomolar range. Potent in vitro activity is also demonstrated against systemic and emerging viruses including Dengue and Ebola.
Use of Nitrile Oxides in Synthesis. A Novel Synthesis of Chalcones, Flavanones, Flavones and Isoflavones
Thomsen, Ib,Torssell, Kurt B. G.
, p. 303 - 308 (2007/10/02)
Novel methodology is developed for a three-step synthesis of chalcones, flavanones, flavones and isoflavones. 1.Salicylaldoxime is chlorinated to the corresponding hydroxamoyl chloride in the presence of pyridine, and cycloadded to styrene and phenylacetylene. 2.The isoxazole derivatives formed are reductively cleaved over Raney-Ni to β-hydroxyketones or 1,3 diketones. 3.Acid-catalyzed cyclization gives the flavonoids.Use of ω-methoxy- or ω-dialkylamino-substituted styrenes (enamines) leads regioselectively to 4-aryl-substituted isoxazoles and derived isoflavones.
