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Relevant academic research and scientific papers

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

Highly Chemoselective Access to 2,2-Diaminobiaryls via Ni-Catalyzed Protecting-Group-Free Coupling of 2-Haloanilines

The development of strategies to access 2,2-diaminobiaryl derivatives via a transition-metal-catalyzed coupling reaction from protecting-group-free starting materials is a challenging task to accomplish, owing to the easy occurrence of undesired side reactions. The exploitation of Ni-catalyzed direct homocoupling of unprotected 2-haloaniline analogues to produce 2,2-diaminobiaryls with a readily available and inexpensive bipyridine ligand has been described. This approach was highlighted by its high chemoselectivity, broad substrate scope, and functional group compatibility. The mechanistic and calculation studies indicated that Ni(0), Ni(I), Ni(II), and Ni(III) species might be involved in the catalytic cycle.

Method for preparing 4, 4'-disubstituted-2, 2'-diaminodiphenyl and hydrochloride thereof through reductive coupling

The invention discloses a method for preparing 4, 4'-disubstituted-2, 2'-diaminodiphenyl and hydrochloride thereof based on 4-substituted nitrobenzene and through reductive coupling. The method comprises the following steps: in the presence of an organic

Method for preparing 4,4'-disubstituted-2,2'-diaminodiphenyl and hydrochloride thereof by continuous flow oxidative coupling method

The invention discloses a method for preparing 4,4'-disubstituted-2,2'-diaminodiphenyl and hydrochloride thereof on the basis of 4-substituted nitrobenzene by a reductive coupling method. The method comprises the following steps: in the presence of an organic solvent, a noble metal catalyst and strong alkali, carrying out catalytic hydrogenation by using hydrogen, generating corresponding 1,2-diphenyl hydrazine from the 4-substituted nitrobenzene, then carrying out rearrangement in a hydrochloric acid-ammonium salt mixed solution, and sequentially carrying out pH adjustment, ethyl acetate precipitation, toluene recrystallization, and acidification and acid precipitation treatment to obtain the 4,4'-disubstituted-2,2'-diaminodiphenyl and hydrochloride thereof; the method has the advantagesof cheap and accessible raw materials, simple and convenient operation process, recyclable catalyst, mild reaction conditions and higher yield, and has wide industrial prospects.

Homocoupling of aryl iodides and bromides using a palladium/indium bimetallic system

Homocoupling of aryl iodides and bromides using catalytic amounts of palladium and stoichiometric amounts of indium proceeded smoothly to afford the corresponding biaryls in good to high yields. Copyright Taylor & Francis, Inc.