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(4-(trifluoromethyl)-1H-imidazol-5-yl)methanol, also known as TFMI, is a chemical compound with the molecular formula C6H6F3NO. It is a white crystalline powder that is soluble in organic solvents but sparingly soluble in water. TFMI is a versatile and valuable compound in the field of medicinal chemistry, as it can be used to introduce the trifluoromethyl group into organic molecules, which can significantly enhance their bioactivity and pharmacokinetic properties.
Used in Pharmaceutical Industry:
(4-(trifluoromethyl)-1H-imidazol-5-yl)methanol is used as a reagent in organic synthesis for the production of pharmaceuticals. It is employed as a building block in the synthesis of various heterocyclic compounds, which are essential in the development of new drugs.
Used in Agrochemical Industry:
(4-(trifluoromethyl)-1H-imidazol-5-yl)methanol is used as a reagent in organic synthesis for the production of agrochemicals. It is used as a key intermediate in the manufacturing of certain fluorinated building blocks that are widely used in the field of agrochemical discovery.
Used in Medicinal Chemistry:
(4-(trifluoromethyl)-1H-imidazol-5-yl)methanol is used as a versatile compound to introduce the trifluoromethyl group into organic molecules, which can significantly enhance their bioactivity and pharmacokinetic properties. This makes TFMI a valuable tool in the development of new pharmaceuticals and agrochemicals with improved efficacy and safety profiles.

59608-85-4

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59608-85-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 59608-85-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,6,0 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 59608-85:
(7*5)+(6*9)+(5*6)+(4*0)+(3*8)+(2*8)+(1*5)=164
164 % 10 = 4
So 59608-85-4 is a valid CAS Registry Number.

59608-85-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name [4-(trifluoromethyl)-1H-imidazol-5-yl]methanol

1.2 Other means of identification

Product number -
Other names (5-trifluoromethyl-1(3)H-imidazol-4-yl)-methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59608-85-4 SDS

59608-85-4Downstream Products

59608-85-4Relevant academic research and scientific papers

Photochemical Perfluoroalkylation of Imidazoles

Kimoto, Hiroshi,Fujii, Shozo,Cohen, Louis A.

, p. 2867 - 2872 (2007/10/02)

Imidazole and its derivatives undergo facile trifluoromethylation or perfluoroalkylation, in methanol solution at ambient temperature, following radical dissociation of RFI by γ or UV irradiation.In the case of imidazole, attack occurs preferen

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

-

, (2015/12/08)

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

-

, (2015/12/08)

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

-

, (2008/06/13)

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

-

, (2008/06/13)

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.

PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

-

, (2008/06/13)

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. "

PHARMACEUTICAL COMPOSITIONS AND METHOD OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

-

, (2008/06/13)

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-methyl-N'-4-(5)-imidazolyl) butyl!thiourea.

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