596113-49-4Relevant academic research and scientific papers
CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF
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, (2018/08/20)
The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
Synthesis of chiral, nonracemic α-sulfanylphosphonates and derivatives
Gulea, Mihaela,Hammerschmidt, Friedrich,Marchand, Patrice,Masson, Serge,Pisljagic, Violeta,Wuggenig, Frank
, p. 1829 - 1836 (2007/10/03)
Optically active α-sulfanylphosphonates and the corresponding methyl sulfides were prepared in three steps starting from chiral, nonracemic (ee 93-97%) α-hydroxyphosphonates obtained by enzymatic resolution. Reaction conditions for the reduction of racemi
