596130-72-2Relevant academic research and scientific papers
Structure-based design of agents targeting the bacterial ribosome
Bower, Justin,Drysdale, Martin,Hebdon, Richard,Jordan, Allan,Lentzen, Georg,Matassova, Natalia,Murchie, Alastair,Powles, Jenifer,Roughley, Stephen
, p. 2455 - 2458 (2003)
Rational structure-based drug design has been applied to the antibiotic thiostrepton, in an attempt to overcome some of its' limitations. The identification of a proposed binding fragment allowed construction of a number of key fragments, which were derivatised to generate a library of potential antibiotics. These were then evaluated to determine their ability to bind to the L11 binding domain of the prokaryotic ribosome and inhibit bacterial protein translation.
