59615-89-3Relevant academic research and scientific papers
Synthesis of 5-substituted 2-ylidene-1,3-thiazolidin-4-one derivatives and evaluation of their anticancer and antioxidant activities
Saied, Khaled F.,Kandeel, Kamal A.,Abdelwahab, Salwa S.,Ahmed, Osama M.
, p. 993 - 1003 (2019/11/16)
[Figure not available: see fulltext.] Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N,S-acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.
Heterocyclic synthesis with thiophene-2-carboxamide
Ahmed, Gamal A.
, p. 74 - 81 (2008/12/22)
3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Gram positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.
POLARIZED KETENE DITHIOACETALS-PART II: SYNTHESIS OF S,S- AND S,N-CYCLIC KETENE DITHIOACETALS AND THEIR TRANSFORMATION TO AZOLES AND 1,3-DITHIOLE-2-THIONES
Ram, Vishnu J.,Haque, Navedul,Singh, S. K.,Nath, M.,Shoeb, A.
, p. 155 - 162 (2007/10/02)
New procedures for the synthesis of azoles (3,4) from 1,3-dithiolanes (2), thiazolidinone (5,6), thiazolines (7,9,10) and 1,3-dithiole-2-thione (8) from active methylene compounds (1a-j) are described.Key words: 1,3-Dithiolane; 1,3-dithiane; 1,3-thiazine; 1,3-dithiole-2-thione; thiazoline; ketene dithioacetal.
SYNTHESIS OF THIENO(2,3-b)THIOPHENES AND RELATED STRUCTURES
El-Shafei, A. K.,Abdel-Ghany, H. A.,Sultan, A. A.,El-Saghier, A. M. M.
, p. 15 - 26 (2007/10/02)
Some new functionally substituted thieno(2,3-b)thiophenes and related compounds were obtained in a one-pot reaction using phase transfer catalysis conditions starting with some active nitriles or active methylene compounds, carbon disulphide or phenyl isothiocyanate and α-chlorocarbethoxy, or α-nitrile electrophiles.The structure of the obtained new compounds was assigned.Key words: Thiophene; thienothiophene; dithiolane; thiazolidinone; thiazoline; thienopyrazole; furopyrazole.
