59653-66-6

Usage

Reaction

Efficient ruthenium catalyst for asymmetric hydrogenation of aryl ketones.

Upstream product

• 72-18-4 L-valine 
• 95-54-5 1,2-diamino-benzene 
• 59592-11-9 N-benzyloxycarbonyl-(1S)-(1-benzimidazol-2-yl)-2-methylpropylamine 
• 13734-41-3 t-Boc-L-valine 
• 133703-84-1 (S)-tert-butyl 1-(2-aminophenylamino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 1419561-77-5 (S)-tert-butyl 1-(1H-benzo[d]imidazol-2-yl)-2-methylpropylcarbamate 

Relevant academic research and scientific papers

α-Amino Acid Derived Benzimidazole-Linked Rhodamines: A Case of Substitution Effect at the Amino Acid Site toward Spiro Ring Opening for Selective Sensing of Al3+ Ions

α-Amino acid derived benzimidazole-linked rhodamines have been synthesized, and their metal ion sensing properties have been evaluated. Experimentally, l-valine- and l-phenylglycine-derived benzimidazole-based rhodamines 1 and 2 selectively recognize Al3+ ion in aqueous CH3CN (CH3CN/H2O 4/1 v/v, 10 mM tris HCl buffer, pH 7.0) over the other cations by exhibiting color and "turn-on" emission changes. In contrast, glycine-derived benzimidazole 3 remains silent in the recognition event and emphasizes the role of α-substitution of amino acid undertaken in the design. The fact has been addressed on the basis of the single-crystal X-ray structures and theoretical calculations. Moreover, pink 1·Al3+ and 2·Al3+ ensembles selectively sensed F- ions over other halides through a discharge of color. Importantly, compounds 1 and 2 are cell permeable and have been used as imaging reagents for the detection of Al3+ uptake in human lung carcinoma cell line A549.

L-Valine derived benzimidazole based bis-urea in enantioselective fluorescence sensing of L-tartrate

l-Valine derived benzimidazole based bis-urea 1 has been designed and synthesized. The bis-urea 1 is found to act as enantioselective chemosensor for tartrate. The sensor shows greater fluorescence response for L-tartrate in DMSO. The enantiomeric fluorescence difference ratio (ef) has been determined to be 2.46. In comparison, less steric receptor 2 exhibits a marginal preference for d-tartrate over the l-tartrate in DMSO and validates the steric role of the substituents around the benzimidazole motif in 1 toward enantioselective recognition of tartrate.

L-Valine-derived simple benzimidazole-based host in selective sensing of Hg(II) ions

A new and an easy-to-make simple benzimidazole-based chemosensor 1, derived from l-valine is reported. The chemosensor effectively recognises Hg 2+ ion in the open cleft in CH3CN containing 0.2% DMSO by exhibiting significant enhance

Hybrid NH2-benzimidazole ligands for efficient Ru-catalyzed asymmetric hydrogenation of aryl ketones

Readily available hybrid NH2/benzimidazole ligands (R-bimaH, 1) dramatically influence the outcome of established Ru-based catalysts during asymmetric hydrogenation of aryl ketones. The benzimidazole functionality results in reversal of the typically observed chiral induction and allows for hydrogenation to be uncharacteristically conducted in nonprotic solvents. The developed systems efficiently catalyzed the AH of a number of ketones in up to 99% ee.

Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the com

Retroviral protease inhibitors

The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.