59660-29-6Relevant academic research and scientific papers
Amidinosulphonic acid derivatives
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, (2008/06/13)
Amidinosulphonic acid derivatives carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'[2-(5-methyl-4-imidazolylmethylthio)-ethyl]amidinosulphonic acid and N-methyl-N'[2-(3-chloropyrid-2-ylmethylthio) ethyl]amidinosulphonic acid, are histamine H2 -receptor antagonists.
IMIDAZOLYL ALKYLGUANIDINE COMPOUNDS
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, (2008/06/13)
The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H 2-antagonists.
CERTAIN THIAZOLES AND OXAZOLES
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, (2008/06/13)
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis 2-((4-methyl-5-imidazolyl)methylthio) ethyl!thiourea and N,N'-bis 2-((4-methyl-5-imidazolyl)methylthio)ethyl!-N"-cyanoguanidine. "
PROCESS FOR PREPARING 2-AMINO-2-ALKYLTHIO-1-NITROETHYLENE COMPOUNDS
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, (2008/06/13)
A process for preparing 2-amino-2-alkylthio-1-nitroethylene compounds by reacting a 1-lower alkylsulfinyl-1-lower alkylthio-2-nitroethylene with an amine. The products of the process are intermediates for the production of histamine H 2-antagonists.
PYRIDYL-ALKYLAMINOETHYLENE COMPOUNDS
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, (2008/06/13)
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-2-((4-methyl-5-imidazolyl) methylthio)ethylamino!-2-2-((3-chloro-2-pyridyl)methylthio) ethylamino!ethylene.
PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS
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, (2015/12/08)
The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
GUANIDINO, THIOUREIDO AND ISOTHIOUREIDO DERIVATIVES CONTAINING IMIDAZOLE GROUPS
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, (2008/06/13)
The compounds are C 2-C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino!propane and 1,3-bis-S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido!propane. The compounds of this invention are inhibitors of H-2 histamine receptors. "
PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS
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, (2008/06/13)
The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.
