59662-46-3

Basic information

• Product Name: 4-(4-N-BUTYLPHENYL)BENZOIC ACID
• Synonyms: RARECHEM AL BO 0889;4'-BUTYLBIPHENYL-4-CARBOXYLIC ACID;4-BUTYL-4'-BIPHENYLCARBOXYLIC ACID;4-N-BUTYLBIPHENYL-4'-CARBOXYLIC ACID;4-(4-N-BUTYLPHENYL)BENZOIC ACID;4-Butyl-4''-carboxybiphenyl;4-Butyl-4'-biphenylcarboxylic acid;[1,1'-Biphenyl]-4-carboxylicacid, 4'-butyl-
• CAS NO: 59662-46-3
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.32
• Product Categories: Biphenyl & Diphenyl ether
• Mol File: 59662-46-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 413.5 °C at 760 mmHg
• Flash Point: 192.9 °C
• Appearance: /
• Density: 1.091±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 4-(4-N-BUTYLPHENYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-N-BUTYLPHENYL)BENZOIC ACID(59662-46-3)
• EPA Substance Registry System: 4-(4-N-BUTYLPHENYL)BENZOIC ACID(59662-46-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 59662-46-3(Hazardous Substances Data)

Usage

Uses

4''-Butylbiphenyl-4-carboxylic Acid is an intermediate used in the preparation of biphenylcarboxylates used as RARβ2 receptor agonist.

Upstream product

• 350792-80-2 (4-butylphenyl)(difluoro)(ethyl)silane 
• 350792-89-1 (4-butylphenyl)(cyclohexyl)(difluoro)silane 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 1451206-56-6 methyl 4’-butyl-[1,1 ‘-biphenyl]-4-carboxylate 
• 350792-82-4 (4-butylphenyl)(dichloro)(cyclohexyl)silane 
• 41492-05-1 p-bromobutylbenzene 
• 155408-84-7 (4-butylphenyl)(dichloro)(ethyl)silane 
• 52709-83-8 4'-n-butyl-4-cyanobiphenyl 

Downstream Products

• 1451207-52-5 C₃₉H₄₂N₂O₅ 
• 1451207-54-7 C₃₈H₄₀N₂O₅ 
• 89111-63-7 4-trans-(4-trans-butylcyclohexyl)cyclohexanecarboxylic acid 
• 61733-31-1 4-(4-n-butylphenyl)-benzoic acid 4'-methoxyphenyl ester 

Relevant articles and documents

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

LINEAR PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Solid phase cross-coupling reaction of aryl(halo)silanes with 4-iodobenzoic acid

Aryl(alkyl)(halo)silanes undergo facile and efficient palladium catalyzed cross-coupling reaction with iodobenzoic acid tethered to the Wang resin. Acid cleavage releases unsymmetrical biaryl carboxylic acids with high conversions, purities and yields.