59662-46-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-N-BUTYLPHENYL)BENZOIC ACID is used as an intermediate in the synthesis of biphenylcarboxylates, which are known to act as RARβ2 receptor agonists. These agonists play a crucial role in the regulation of cellular processes and have potential therapeutic applications in the treatment of various diseases and conditions.
As an intermediate in the preparation of biphenylcarboxylates, 4-(4-N-BUTYLPHENYL)BENZOIC ACID contributes to the development of new drugs and therapies that target the RARβ2 receptor, potentially leading to improved treatment options for patients.

Upstream product

• 350792-80-2 (4-butylphenyl)(difluoro)(ethyl)silane 
• 350792-89-1 (4-butylphenyl)(cyclohexyl)(difluoro)silane 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 350792-82-4 (4-butylphenyl)(dichloro)(cyclohexyl)silane 
• 41492-05-1 p-bromobutylbenzene 
• 52709-83-8 4'-n-butyl-4-cyanobiphenyl 
• 1451206-56-6 methyl 4’-butyl-[1,1 ‘-biphenyl]-4-carboxylate 
• 155408-84-7 (4-butylphenyl)(dichloro)(ethyl)silane 

Downstream Products

• 61733-31-1 4-(4-n-butylphenyl)-benzoic acid 4'-methoxyphenyl ester 
• 89111-63-7 4-trans-(4-trans-butylcyclohexyl)cyclohexanecarboxylic acid 
• 1451207-54-7 C₃₈H₄₀N₂O₅ 
• 1451207-52-5 C₃₉H₄₂N₂O₅ 

Relevant academic research and scientific papers

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

LINEAR PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

LINEAR PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Solid phase cross-coupling reaction of aryl(halo)silanes with 4-iodobenzoic acid

Aryl(alkyl)(halo)silanes undergo facile and efficient palladium catalyzed cross-coupling reaction with iodobenzoic acid tethered to the Wang resin. Acid cleavage releases unsymmetrical biaryl carboxylic acids with high conversions, purities and yields.

Solid-phase cross-coupling reaction of aryl(fluoro)silanes with 4- iodobenzoic acid

Aryl(alkyl)(difluoro)silanes undergo a facile and efficient palladium- catalyzed cross-coupling reaction with iodobenzoic acid tethered to the Wang resin. Acid cleavage releases unsymmetrical biaryl carboxylic acids with high conversions, purities, and yields. (C) 2000 Elsevier Science Ltd.

Biphenyl esters and liquid crystalline mixtures comprising them

Biphenyl esters of the formula STR1 wherein X is --CO--O-- or --O--CO-- and R1 and R2 each are alkyl or alkoxy of 1 - 8 carbon atoms, enlarge significantly the temperature range of the nematic phase of liquid-crystalline compositions without adversely affecting other properties.