59673-48-2Relevant academic research and scientific papers
BTK Inhibitors and uses thereof
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Paragraph 1812; 1818-1820, (2020/05/02)
The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.
Synthesis of Potentially Bioactive 6-Bromobenzo[f]isoindolinium Bromides by Base-Catalyzed Intramolecular [4+2]-Cycloaddition
Chukhadzhian,Gevorgyan,Ayrapetyan,Chukhadzhian, El. O.,Shahkhatuni,Mkrtchyan,Panosyan
, p. 1156 - 1160 (2018/10/24)
Intramolecular cyclization of bromides of diethyl-, dipropyl-, and penthamethylenepropargyl[3-(4-bromophenyl)prop-2-ynyl]ammonium into 6-bromobenzo[f]isoindolinium bromides catalyzed with bases occurs with moderate self-heating. The morpholine analog even
Methods for Preparating Propargylamines through Metal-Free Decarboxylative Three-Component Coupling Reaction
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Paragraph 0136-0139, (2016/10/09)
The present invention relates to a method for producing propargylamine or derivatives thereof through a decarboxylative reaction without using a metal catalyst by making alkynyl carboxylic acid, aldehyde and amine react. According to the method of the pre
Metal-free decarboxylative three-component coupling reaction for the synthesis of propargylamines
Park, Kyungho,Heo, Yumi,Lee, Sunwoo
, p. 3322 - 3325 (2013/07/26)
A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in CH3CN at 65 °C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.
