59678-46-5

Basic information

• Product Name: ENTEROCIN
• Synonyms: ENTEROCIN;(3R,8R)-7α-Benzoyl-4,4a,5,6,7,7a-hexahydro-4aα,6α,7aα,8-tetrahydroxy-5β-(4-methoxy-2-oxo-2H-pyran-6-yl)-3β,6-methanocyclopenta[c]pyran-1(3H)-one;Vulgamycin;3,6-Methanocyclopenta(C)pyran-1(3H)-one, 7-benzoylhexahydro-4A,6,7A,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-, (3R,4ar,5S,6S,7S,7as,8R)-;Aids035399;Aids-035399;Enterocin, vulgamycin;VulgaMycin, A 5294, WS 8096
• CAS NO: 59678-46-5
• Molecular Formula: C22H20O10
• Molecular Weight: 444.39
• Product Categories: Antibiotic
• Mol File: 59678-46-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 726.3 °C at 760 mmHg
• Flash Point: 257.4 °C
• Appearance: /
• Density: 1.67 g/cm³
• Vapor Pressure: 3.83E-22mmHg at 25°C
• Refractive Index: 1.712
• Solubility: Soluble in DMSO
• PKA: 10.86±0.70(Predicted)
• CAS DataBase Reference: ENTEROCIN(CAS DataBase Reference)
• NIST Chemistry Reference: ENTEROCIN(59678-46-5)
• EPA Substance Registry System: ENTEROCIN(59678-46-5)

Safety Data

• Hazardous Substances Data: 59678-46-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 59678-46-5 differently. You can refer to the following data:
1. Enterocin is a potent antibiotic with broad spectrum activity against Gram positive and Gram negative bacteria. Although the mechanism of action of enterocin is unknown, it acts synergistically with streptomycin and chloramphenicol. The genetics of enterocin biosynthesis have been extensively investigated. Enterocin is a small molecular weight secondary metabolite and should not be confused with bacterial proteins isolated from Enterococci, generically referred to as "enterocins".
2. Enterocin is a potent antibiotic with broad spectrum activity against Gram +ve and Gram -ve bacteria.

Biological Activity

enterocin is an antibiotic isolated from cultures of two strains of streptomyces, streptomyces candidus var. enterostaticus ws-8096 and variant m-127 of streptomyces viridochromogenes. this antibiotic shows activity against gram-positive and gram-negative bacteria, especially against the enterobacteriaceae [1]. enterocin was named for its strong activity against enterobacteriaceae.the elementary analysis and mass spectroscopic measurement suggested that the molecular formula was c72h20o10. the ultraviolet absorption gave two maximal peaks at 250 nm and 283 nm in methanol [1]. the mechanism of enterocin is unknown. enterocin acts synergistically with streptomycin and chloramphenicol. the genetics of enterocin biosynthesis has been extensively investigated. enterocin is a small molecular weight secondary metabolite [1].

references

[1] miyairi n, sakai h e i i, konomi t, et al. enterocin, a new antibiotic [j]. the journal of antibiotics, 1976, 29(3): 227-235.

InChI:InChI=1/C22H20O10/c1-30-11-7-12(31-14(23)8-11)16-20(27)9-13-18(25)21(16,28)17(22(20,29)19(26)32-13)15(24)10-5-3-2-4-6-10/h2-8,13,16-18,25,27-29H,9H2,1H3/t13-,16-,17+,18?,20-,21+,22-/m1/s1