596792-58-4Relevant academic research and scientific papers
A concise route to the right wing of ciguatoxin
Tatami, Atsushi,Inoue, Masayuki,Uehara, Hisatoshi,Hirama, Masahiro
, p. 5229 - 5233 (2007/10/03)
A concise route to the HIJKLM-ring fragment 10 of ciguatoxin (CTX) and 51-hydroxyCTX3C was developed in which oxiranyl anion addition and intramolecular carbonyl olefination were utilized as key transformations. The present procedure requires only 23 steps from the I-ring 5, while 35 steps were employed in a previous synthesis of the corresponding right wing 11 of CTX3C. The high efficiency of the present synthesis ensures a supply of 10 for total synthesis and biomedical applications.
