596807-19-1

Upstream product

• 524940-49-6 C₇₁H₇₀F₂N₇O₁₆P₃ 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 214778-10-6 3-methylamino-4-nitro-benzoic acid 
• 524940-54-3 4-amino-3-methylamino-benzoic acid tert-butyl ester 
• 524940-53-2 3-methylamino-4-nitro-benzoic acid tert-butyl ester 
• 524940-55-4 2-methoxycarbonylmethyl-3H-benzoimidazole-5-carboxylic acid methyl ester 
• 160515-05-9 2-amino-3-(bis-benzyloxy-phosphoryl)-propionic acid methyl ester 
• 524940-50-9 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 524940-51-0 3-(bis-benzyloxy-phosphoryl)-2-tert-butoxycarbonylamino-propionic acid 
• 596802-33-4 2-(6-Methoxycarbonyl-1H-benzoimidazol-2-ylmethyl)-3-methyl-3H-benzoimidazole-5-carboxylic acid tert-butyl ester 
• 524940-47-4 2-[Difluoro-(6-methoxycarbonyl-1H-benzoimidazol-2-yl)-methyl]-3-methyl-3H-benzoimidazole-5-carboxylic acid tert-butyl ester 
• 596802-96-9 2-[(6-Carboxy-1H-benzoimidazol-2-yl)-difluoro-methyl]-3-methyl-3H-benzoimidazole-5-carboxylic acid tert-butyl ester 
• 524940-46-3 2-[2-amino-3-(bis-benzyloxy-phosphoryl)-propionylamino]-3-(bis-benzyloxy-phosphoryl)-propionic acid methyl ester 
• 524940-48-5 2-({6-[2-(bis-benzyloxy-phosphoryl)-1-methoxycarbonyl-ethylcarbamoyl]-1H-benzoimidazol-2-yl}-difluoro-methyl)-3-methyl-3H-benzoimidazole-5-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease

Screening of a diverse set of bisbenzimidazoles for inhibition of the hepatitis C virus (HCV) serine protease NS3/NS4A led to the identification of a potent Zn2+-dependent inhibitor (1). Optimization of this screening hit afforded a 10-fold more potent inhibitor (46) under Zn2+ conditions (Ki=27 nM). This compound (46) binds also to NS3/NS4A in a Zn2+ independent fashion (Ki=1 μM). The SAR of this class of compounds under Zn2+ conditions is highly divergent compared to the SAR in the absence of Zn2+, suggesting two distinct binding modes.