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CAS

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596818-05-2

1-(2-Thiazolyl)-4-piperidinamine, also known as TAK-242, is a small molecule inhibitor with significant anti-inflammatory properties. It is recognized for its potential therapeutic applications in a range of inflammatory conditions, including sepsis, arthritis, and autoimmune disorders. TAK-242 operates by selectively targeting toll-like receptor 4 (TLR4), a key player in the immune response to bacterial infections and in the promotion of inflammation. By inhibiting TLR4 signaling, TAK-242 effectively reduces the production of pro-inflammatory cytokines and modulates the immune response, positioning it as a promising candidate for the development of novel anti-inflammatory drugs.

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  • 596818-05-2 Structure

  • Basic information

    1. Product Name: 1-(2-Thiazolyl)-4-piperidinamine
    2. Synonyms: N-2'-THIAZOLE-4-AMINOPIPERIDINE;4-Piperidinamine,1-(2-thiazolyl)-(9CI);1-(2-Thiazolyl)-4-piperidinamine;1-(1,3-thiazol-2-yl)piperidin-4-amine dihydrochloride
    3. CAS NO:596818-05-2
    4. Molecular Formula: C8H13N3S
    5. Molecular Weight: 183.27
    6. EINECS: N/A
    7. Product Categories: PIPERIDINE
    8. Mol File: 596818-05-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 308.2 °C at 760 mmHg
    3. Flash Point: 140.2 °C
    4. Appearance: /
    5. Density: 1.205 g/cm3
    6. Refractive Index: 1.587
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 9.68±0.20(Predicted)
    10. CAS DataBase Reference: 1-(2-Thiazolyl)-4-piperidinamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(2-Thiazolyl)-4-piperidinamine(596818-05-2)
    12. EPA Substance Registry System: 1-(2-Thiazolyl)-4-piperidinamine(596818-05-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 596818-05-2(Hazardous Substances Data)

596818-05-2 Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Thiazolyl)-4-piperidinamine is used as an anti-inflammatory agent for its ability to selectively target and inhibit toll-like receptor 4 (TLR4), thereby reducing the production of pro-inflammatory cytokines and dampening the immune response in various inflammatory diseases.
Used in Sepsis Treatment:
In the field of critical care medicine, 1-(2-Thiazolyl)-4-piperidinamine is used as a therapeutic intervention for sepsis, leveraging its capacity to mitigate the overactive immune response and the associated inflammation that can lead to organ failure and other complications.
Used in Arthritis Management:
1-(2-Thiazolyl)-4-piperidinamine is utilized as a treatment for arthritis, aiming to alleviate symptoms and reduce the inflammation associated with the condition by inhibiting TLR4 signaling pathways.
Used in Autoimmune Disorders:
In the context of autoimmune disorders, 1-(2-Thiazolyl)-4-piperidinamine is employed as a potential therapeutic agent to manage inflammation and modulate the immune system's response, offering a new approach to treating conditions where the immune system mistakenly attacks the body's own tissues.

Check Digit Verification of cas no

The CAS Registry Mumber 596818-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,6,8,1 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 596818-05:
(8*5)+(7*9)+(6*6)+(5*8)+(4*1)+(3*8)+(2*0)+(1*5)=212
212 % 10 = 2
So 596818-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H13N3S/c9-7-1-4-11(5-2-7)8-10-3-6-12-8/h3,6-7H,1-2,4-5,9H2

596818-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(1,3-thiazol-2-yl)piperidin-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:596818-05-2 SDS

596818-05-2Upstream product

596818-05-2Downstream Products

596818-05-2Relevant articles and documents

NEW COMPOUNDS

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Page/Page column 39; 40, (2008/06/13)

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

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