596823-70-0Relevant academic research and scientific papers
Pyrrolopyridine potassium channel openers
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Page 17, (2010/02/08)
Novel pyrrolopyridine compounds of formula (I), and their derivatives open potassium channels and are useful for treating a variety of diseases modulated by potassium channels.
The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles
Turner, Sean C.,Carroll, William A.,White, Tammie K.,Gopalakrishnan, Murali,Coghlan, Michael J.,Shieh, Char-Chang,Zhang, Xu-Feng,Parihar, Ashutosh S.,Buckner, Steven A.,Milicic, Ivan,Sullivan, James P.
, p. 2003 - 2007 (2007/10/03)
2-Amino-4-azaindoles have been identified as a structurally novel class of BKCa channel openers. Their synthesis from 2-chloro-3-nitropyridine is described together with their in vitro properties assessed by 86Rb+ efflux and whole-cell patch-clamp assays using HEK293 cells stably transfected with the BKCa α subunit. In vitro functional characterization of BKCa channel opening activity was also assessed by measurement of relaxation of smooth muscle tissue strips obtained from Landrace pig bladders. The preliminary SAR data indicate the importance of steric bulk around the 2-amino substituent.
