59685-36-8

Upstream product

• 75509-52-3 (2α,3aβ,6aα,9aα)-(+/-)-2-<(dimethylamino)-methyl>decahydropyrido<2,1,6-de>quinolizin-1(2H)-one 
• 75509-51-2 (3aR,6aR,9aR)-2-[1-Dimethylamino-meth-(Z)-ylidene]-decahydro-pyrido[2,1,6-de]quinolizin-1-one 
• 1130-59-2 dodecahydro-9b-bora-phenalene 
• 75543-75-8 (2α,3aα,6aα,9aα)-(+/-)-decahydro-2-methylpyrido<2,1,6-de>quinolizin-1(2H)-one 
• 75556-10-4 (3aα,6aβ,9aβ)-(+/-)-decahydropyrido<2,1,6-de>quinolizin-1(2H)-one 
• 75509-50-1 trans-(+/-)-1,2,3,3a,4,5,6,6a,7,8-decahydropyrido<2,1,6-de>quinolizine 
• 75556-08-0 (1α,3aβ,6aα,9aα)-(+/-)-dodecahydropyrido<2,1,6-de>quinolizin-1-ol 
• 138770-30-6 [(2R,4S,6S,9aS)-2-(tert-Butyl-dimethyl-silanyloxy)-6-ethoxycarbonylmethyl-octahydro-quinolizin-4-yl]-acetic acid ethyl ester 
• 138770-30-6 [(2S,6R,9aR)-2-(tert-Butyl-dimethyl-silanyloxy)-6-ethoxycarbonylmethyl-octahydro-quinolizin-4-yl]-acetic acid ethyl ester 
• 138770-27-1 (E)-(S)-6-((2R,6R)-6-Ethoxycarbonylmethyl-piperidin-2-yl)-5-hydroxy-hex-3-enoic acid ethyl ester 
• 138770-28-2 ((2S,6R,9aR)-6-Ethoxycarbonylmethyl-2-hydroxy-octahydro-quinolizin-4-yl)-acetic acid ethyl ester 
• 138770-26-0 (E)-4-((2S,3aR,7R)-7-Ethoxycarbonylmethyl-hexahydro-isoxazolo[2,3-a]pyridin-2-yl)-but-3-enoic acid ethyl ester 
• 138770-32-8 (3aS,5R,6aS,9aS)-5-(tert-Butyl-dimethyl-silanyloxy)-decahydro-pyrido[2,1,6-de]quinolizin-2-one 
• 138770-33-9 (2R,3aR,6aS,9aS)-2-(tert-Butyl-dimethyl-silanyloxy)-5-methylene-dodecahydro-pyrido[2,1,6-de]quinolizine 

Relevant academic research and scientific papers

Combining two-directional synthesis and tandem reactions:? an efficient strategy for the total syntheses of (±)-hippodamine and (±)-epi-hippodamine

Two-directional total stereoselective syntheses of (±)-hippodamine and (±)-epi-hippodamine, utilising a tandem deprotection/intramolecular double Michael addition sequence as the key step, are presented.

Nitrone Cycloaddition-based Entry to the Coccinelline Alkaloid Skeleton: Synthesis of (+/-)-epi-Hippodamine

Synthesis of intermediate 13 possessing the perhydropyridoquinolizine skeleton of the coccinelline alkaloids and conversion to epi-hippodamine 20 was accomplished with stereochemical control arising from a key cycloaddition reaction of nitrone 2 with ethyl hexa-3,5-dienoate.

SYNTHESIS OF THE LADYBUG DEFENSIVE AGENTS (+-)-HIPPODAMINE, (+-)-CONVERGINE, (+-)-HIPPOCASINE AND (+-)-HIPPOCASINE OXIDE

The total syntheses of the ladybug defensive agents (+-)-hippoidamine, (+-)-convergine, (+-)-hippocasine, and (+-)-hippocasine oxide are described starting from perhydroboraphenalene.