59697-91-5

Upstream product

• 16141-22-3 ethyl 3-hydroxy-2-phenylbutanoate 
• 507233-69-4 triphenyl bismuth ⁽²⁺⁾; dichloride 
• 623-70-1 ethyl (E)-crotonate 
• 541-41-3 chloroformic acid ethyl ester 
• 2687-12-9 cinnamyl chloride 

Downstream Products

• 433962-85-7 2-Benzyl-3-{4-[4-((S)-1-cyclohexyl-ethylcarbamoyl)-2-phenyl-quinolin-3-ylmethyl]-piperazin-1-yl}-propionic acid ethyl ester 

Relevant academic research and scientific papers

A convenient synthesis of α-substituted β,γ-unsaturated ketones and esters via the direct addition of substituted allylic zinc reagents prepared by direct insertion

A practical and convenient procedure for the synthesis of α-substituted β,γ-unsaturated ketones and esters has been developed. Substituted allylic zinc reagents, prepared via direct metal insertion in substituted allylic halides, react readily with a broad range of acid chlorides and chloroformates furnishing the corresponding α-substituted β,γ-unsaturated ketones and esters in high yield and perfect regioselectivity. Georg Thieme Verlag Stuttgart · New York.