59699-54-6

Upstream product

• 6315-89-5 3,4-dimethoxyaniline 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 93-07-2 Veratric acid 

Downstream Products

• 156085-93-7 N-(3,4-Dimethoxy-phenyl)-3,4-dimethoxy-thiobenzamide 
• 59699-53-5 N-(3,4-dimethoxyphenyl)-N-methyl-3,4-dimethoxybenzamide 
• 156086-04-3 2-(3,4-Dimethoxy-phenyl)-5,6-dimethoxy-benzothiazole 

Relevant academic research and scientific papers

Aerobic oxidative homocoupling reaction of anilides using heterogeneous metal catalysts

We have developed a heterogeneous catalytic oxidative homocoupling reaction of dimethoxyanilides under an oxygen atmosphere. The resulting homo-dimers are useful for the construction of heterocycles, demonstrating the potential of heterogeneous metal catalysts.

Restraining the flexibility of the central linker in terameprocol results in constrained analogs with improved growth inhibitory activity

The semi-synthetic lignan terameprocol inhibits the transcription of several inflammatory and oncogenic genes and has been evaluated for its anti-cancer properties. Here we investigated the effect of restricting the flexibility of the carbon linker connecting the terminal rings of terameprocol on its growth inhibitory activity. Conformational restriction was explored by introducing unsaturation, inserting polar entities with limited flexibility and cyclization of the connecting linker. Twenty three compounds were synthesized and evaluated on a panel of malignant human cells. The most promising compounds were those with non-polar linkers, as seen in butadiene 1a and the cyclized benzylideneindane analog 7. Both compounds were more potent than terameprocol on pancreatic BxPC-3 cells with GI50 values of 3.4 and 8.1 μM, respectively. Selected isomers of 1a (E,E) and 7 (Z) adopted low energy bent conformations that mimicked the low energy conformer of terameprocol. It is tempting to propose that conformational similarity to terameprocol may have contributed to their good activity. The scaffolds of 1a and 7 should be further investigated for their anticancer potential.

Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity.

Novel applications of hypervalent iodine: PIFA mediated synthesis of benzo[c]phenanthiridines and benzo[c]phenanthridinones

A short and efficient access to benzo[c]phenanthridines and phenanthridinones is achieved by the action of phenyliodine(III)-bis(trifluoroacetate) (PIFA) on properly substituted benzylnaphthylamines and naphthylbenzamides, respectively. This reagent promotes a non-phenolic oxidative biaryl coupling process, the key step of the synthesis. A study of the electronic and steric requirements of the substrates is carried out since, in some cases, dimerization processes prevail over intramolecular cyclization. A mechanistic proposal is also included.