59722-34-8

Upstream product

• 64931-04-0 1,2-bis<(methylsulfonyl)oxy>benzene 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 862183-37-7 (R)-1-chloro-3-(2-mesyloxyphenoxy)-3-phenylpropane 
• 4265-27-4 2-n-butylbenzo[b]furan 
• 59722-52-0 O-ethyl O-[2-(methanesulfonyloxy)phenyl] S-n-propyl phosphorothiolate 
• 862183-39-9 (R)-1-iodo-3-(2-mesyloxyphenoxy)-3-phenylpropane 
• 862183-41-3 (R)-N-methyl-3-(2-hydroxyphenoxy)-3-phenyl-1-propylamine 
• 89232-62-2 Methanesulfonic acid 2-aminooxy-phenyl ester 

Relevant academic research and scientific papers

NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS

The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Pharmaceutically active amines

The aromatic amines (I), alkyl amines (II), bicyclic amines (III). STR1 cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmaceutical agents for treating a number of conditions including spinal trauma, mild and/or moderate to severe head injury, etc. Also disclosed is a method of treatment using the 3,4-dihydrobenzopyrans (XI).

Synthesis of Phenoxyamines

Treatment of phenols with 2,4-dinitrophenoxyamine leads to the synthesis of phenoxyamines through an amine exchange reaction.Yields for this reaction are sensitive to the pKa of the phenol in a manner explainable in terms of a competing bimolecular decomposition reaction involving the 2,4-dinitrophenoxyamines.By use of an appropriately sustituted phenol, this phenomenon can be exploited to give high yields of phenoxyamines having oxygenated substitution patterns that were unattainable by previous methods.